病理显示 s100- 和ini 丢失，要尽快去做放射治疗/质子/重离子
进展太快了。ini缺失手术全切基本2-3个月就会涨到之前大小，s100- 还稍微好点，但也很快
大部分脊索瘤病都是s100+
S100是神经类的表达，阳性(s100+)说明是神经来源的肿瘤（神经鞘瘤或神经纤维瘤）
INI1应该是指代：integrase interactor 1 中文名字 整合酶1
多数恶性肿瘤ini1 缺失。发展迅速。生长迅猛。去分化型/低分化型脊索瘤多为 ini缺失。
低分化/去分化肿瘤 更容易转移
其他文献
46l46命354口@/s めRI犯2706:15Google目このぺ一ジを 日本語国で表示翻訳英
46l46命354口@/sめRI犯2706：15 google目このぺ一ジを日本語国で表示翻訳英
microscope:
显微镜：
1. Conventional (or classic) chordoma is the mostcommon form of chordoma. It is composed of aunique cell type that resembles notochordal cellsand can have areas of chondroid appearance.
1.传统(或经典)脊索瘤是脊索瘤最常见的形式。它是由一个独特的细胞类型，类似脊索细胞和可以有软骨样外观的区域。
2. Poorly differentiated chordoma is a recentlyidentifiled subtype. Ilt can be more aggressive andfaster growing than conventional chordoma, and ismore common in pediatric and young adult patients, as well as in skull base and cervical patients. To helpmake a diagnosis of poorly differentiated chordoma, a pathologist can test a tumor sample for loss ofexpression of a protein called INI1. Nearly all poorlydifferentiated chordomas are INI1-negative, meaningthey do not express the INI1 protein.
2.低分化脊索瘤是一种新近鉴定的亚型。ILT比传统脊索瘤具有更强的侵袭性和更快的生长速度，在儿童和年轻成人患者以及颅底和颈部患者中更常见。为了帮助诊断低分化脊索瘤，病理学家可以检测肿瘤样本中一种名为INI 1的蛋白的表达缺失。几乎所有低分化脊索瘤都是INI 1阴性，也就是说他们不表达INI 1蛋白。
3. Dedifferentiated chordoma is more aggressiveand generally grows faster than the other types ofchordoma, and is more likely to metastasize thanconventional chordoma. It can also have loss of theINI1 gene, but this is not common. This type of
3.去分化脊索瘤比其他类型脊索瘤侵袭性更强，生长速度更快，比传统脊索瘤更容易转移。它也可能有INI 1基因的缺失，但这并不常见。这种类型的
chordoma is rare, occurring in only about 5 percentof patients, and is more common in pediatricpatients.
脊索瘤是罕见的，仅发生在大约5%的病人，更常见于儿科患者。
4. Chondroid chordoma is a term more commonlyused in the past when it was difficult to distinguishconventional chordoma from chondrosarcoma. Thisis no longer a problem because brachyury is
4.脊索瘤是过去比较常用的术语，当时很难区分传统的脊索瘤和软骨肉瘤。这不再是一个问题，因为布鲁里是
expressed in nearly all conventional chordomas,
几乎在所有传统脊索瘤中都有表达，
making them easier to distinguish from cartilaginoustumors like chondrosarcoma that do not express
使它们更容易与软骨肉瘤等不表达软骨肉瘤的软骨瘤区分开来。
brachyury. There is no evidence that chordomas witha chondroid appearance behave differently than
布鲁里。没有证据表明软骨样的脊索瘤的表现与软骨样瘤的行为不同。
conventional types
